Biology · Lesson 19
Fungi and Protists
Put yeast in warm sugary water and a balloon on the bottle, and the balloon slowly fills with gas. Fungi and protists are mostly small, but they bake our bread, feed our forests and cause one of the deadliest diseases on Earth.
This lesson meets the two groups of eukaryotes that are neither plants nor animals.
- 1The fungal body
- 2Spores and life cycles
- 3Decomposers and partners
- 4Yeast and fermentation
- 5Penicillin and fungal disease
- 6Protists
- 7Malaria
- 8Diatoms and oxygen
- 9How do we know?
1. The fungal body
Animals, plants, fungi and protists are all eukaryotes: their cells share the same basic organization (see UCMP). The Classification lesson shows where they sit in the tree of life, and Microbiology and Immunity looks at the smallest of them as microbes.
A fungus is built from thin threads called hyphae. The whole tangle of hyphae is the mycelium, the body of the fungus. A mushroom is only the part that makes spores, called a sporocarp (see UCMP).
Fungal cell walls contain chitin, the same tough material found in the outer skeletons of insects and spiders (see UCMP).
Fungi cannot make their own food like plants, nor swallow it like animals. Their hyphae grow through wood, soil or cheese, give out digestive enzymes and absorb the nutrients that are freed (see UCMP).
2. Spores and life cycles
Fungi spread by spores. In a mushroom, spores are made by meiosis on its gills, and each spore can grow into new hyphae (see UCMP).
A typical life cycle runs like this (see UCMP):
- hyphae from two different fungi meet and fuse, but their nuclei stay separate, so each cell has two nuclei;
- this two-nucleus stage can grow for years;
- at last the nuclei fuse and undergo meiosis, making new spores.
Hyphae can also make spores without meiosis, and some fungi have lost sex altogether. Yeasts mostly reproduce asexually rather than by spores (see UCMP).
3. Decomposers and partners
By breaking down dead material, fungi return nutrients to the ecosystem (see UCMP). Most fungi feed on dead or decaying matter (see UCMP).
Most plants rely on a fungus living in their roots. Root and fungus together are a mycorrhiza, meaning fungal root. The fungus soaks up water and nutrients over a wide area, and the plant pays it in sugars from photosynthesis (see UCMP). The Plant Biology lesson follows that water up through the plant.
A lichen is not a single organism. It is mostly fungal threads, with cells of a green alga or a cyanobacterium living among them (see UCMP).
4. Yeast and fermentation
Baker's yeast, Saccharomyces cerevisiae, is a single-celled fungus. When it ferments sugar it makes alcohol and carbon dioxide (see Parapouli and others). Fungi give us the bubbles in bread, champagne and beer (see UCMP). In bread the gas makes the dough rise; in beer the alcohol is the point.
Yeast is sensitive to temperature. One study found that S. cerevisiae grows best at about 32 °C and stops growing above about 45 °C (see Salvadó and others).
Explore: a yeast and balloon model
Turn on JavaScript to change the temperature and sugar. What the model shows for some settings:
- At 30 °C with 10 g of sugar, the model gives 82 units of gas. That is near the model's best temperature, so the balloon fills fastest. The yeast turns sugar into carbon dioxide and alcohol.
- At 10 °C with 10 g of sugar, the model gives 9 units of gas. That is below the best temperature, so the yeast works slowly. The yeast turns sugar into carbon dioxide and alcohol.
- At 45 °C it is too hot: in the model the yeast stops working, so the balloon stays flat.
- With no sugar, the yeast has nothing to ferment, so no carbon dioxide forms and the balloon stays flat.
- At 30 °C with 20 g of sugar, the model gives 98 units of gas. That is near the model's best temperature, so the balloon fills fastest. The yeast turns sugar into carbon dioxide and alcohol.
A model, not a measurement. The curve's start, peak and end follow the growth temperatures of S. cerevisiae from Salvadó and others; the gas units, the sugar effect and the balloon size are invented to show the idea.
5. Penicillin and fungal disease
Fungi give us drugs such as penicillin and other antibiotics (see UCMP). Penicillin comes from the mold Penicillium, which Alexander Fleming noticed killing bacteria in 1928 (see Nobel biography).
Fungi also cause disease. In people they cause ringworm, athlete's foot and some more serious illnesses. Fungi are chemically and genetically closer to animals than other organisms are, which makes fungal infections hard to treat without harming the patient. In crops, fungi cause rusts, smuts and rots (see UCMP).
6. Protists
A protist is any eukaryote that is not a true animal, plant or fungus. Most are single cells (see Britannica). Many scientists no longer treat protists as a real natural group: it is a convenient label for what is left over (see Britannica).
The microscopic forms were long split into two informal groups (see Britannica):
- algae, the “minute plants”, which photosynthesize;
- protozoa, the “first animals”, such as amoebas and the malaria parasite.
Slime molds were long filed with the fungi, but they are now known to be quite unrelated to them. Plasmodial slime molds are giant single cells with thousands of nuclei. Cellular slime molds live as separate amoeba-like cells until a chemical signal makes them gather into a swarm (see UCMP).
Explore: fungus, protist, plant or animal?
Turn on JavaScript to play. Here are the answers:
| Organism | Group | Why |
|---|---|---|
| Baker's yeast | Fungus | Yeast is a fungus. It ferments sugar. |
| Penicillium mold | Fungus | This mold gave us penicillin. |
| A cluster of mushrooms | Fungus | A mushroom is the spore-making part of a fungus. |
| A diatom in a glass shell | Protist | Diatoms are photosynthetic protists with silica shells. |
| Plasmodium, the malaria parasite | Protist | Plasmodium is a protozoan, a protist. |
| Physarum, a plasmodial slime mold | Protist | Slime molds were once filed with fungi, but they are not related to them. |
| A palm tree | Plant | A palm tree is a plant. |
| A spider | Animal | A spider is an animal. Its exoskeleton contains chitin, like fungal cell walls. |
Groups from UCMP: Eukaryota, UCMP: Fungi, UCMP: Fungal morphology, UCMP: Diatoms, UCMP: Slime molds and Britannica.
7. Malaria: a protist that kills
Malaria is caused by Plasmodium parasites, spread by the bites of infected female Anopheles mosquitoes. It does not spread from person to person. Five species infect people; P. falciparum and P. vivax are the greatest threat (see WHO).
In 2024 there were an estimated 282 million cases and 610 000 deaths in 80 countries. The WHO African Region carried about 95% of both. There, children under five made up about 76% of malaria deaths (see WHO). Yet malaria is preventable and curable (see WHO).
The parasite needs two hosts, a person and a mosquito (see CDC). Inside the mosquito, its part of the cycle takes about 9 to 18 days (see CDC).
Explore: step through the malaria life cycle
Turn on JavaScript to step through the cycle. The steps are:
- Bite: an infected female Anopheles mosquito takes a blood meal and injects sporozoites into a person.
- Liver: the sporozoites infect liver cells and mature into schizonts, which burst and release merozoites.
- Red blood cells: merozoites infect red blood cells and multiply. The cells burst and release more merozoites. These blood stages cause the illness.
- Gametocytes: some parasites in the blood turn into male and female sexual stages, the gametocytes.
- Mosquito gut: another mosquito sucks up gametocytes. In its stomach they form zygotes, which invade the gut wall and grow into oocysts.
- Salivary glands: the oocysts burst and release sporozoites, which move to the mosquito's salivary glands, ready for the next bite.
Adapted and simplified from the life-cycle description in CDC DPDx: Malaria.
8. Diatoms and the oxygen we breathe
Diatoms are algae that live inside glass-like shells of silica. They are very common in ocean and freshwater plankton, and because they photosynthesize they are an important food for sea life (see UCMP).
Scientists estimate that roughly half of Earth's oxygen production comes from the ocean, mostly from plankton: drifting algae, plants and some bacteria. The exact share is hard to measure because plankton numbers keep changing, and ocean life uses up roughly as much oxygen as it makes (see NOAA). So be wary of any exact figure for how much of your breath comes from diatoms.
9. How do we know?
Much of this story turned on microscopes, and on people willing to argue that two organisms could live as one.
- 1677 Antonie van Leeuwenhoek's letter on the “little animals” he saw in water through his home-made lenses is published by the Royal Society. (Lane)
- 1866 Ernst Haeckel proposes a separate kingdom, Protista, for living things that are neither plants nor animals, six years after John Hogg suggested the name Protoctista. (Britannica)
- 1867 Simon Schwendener announces that lichens are fungi living together with algae. Leading lichen experts reject his “dual hypothesis” until the end of the century. (Honegger)
- 1885 Albert Bernhard Frank reports fungi wrapped around tree roots, describes the partnership as mutual feeding, and coins the word mycorrhiza. (Trappe; Frank)
- 1897 Ronald Ross reports strange pigmented cells in two mosquitoes fed on malarial blood. He wins the Nobel Prize in 1902 for showing how malaria enters the body. (Ross; Nobel Prize)
- 1907 Alphonse Laveran wins the Nobel Prize for his work on protozoa as causes of disease. (Nobel Prize)
- 1928 Alexander Fleming sees that a mold growing by accident on a plate of staphylococcus bacteria has left a bacteria-free circle around it. He publishes on penicillin the next year. (Nobel biography; Fleming)
- 1940 Ernst Chain, Howard Florey and colleagues show that penicillin works as a medicine. Fleming, Chain and Florey share the Nobel Prize in 1945. (Chain and others; Nobel Prize)
Quiz: Fungi and protists check
Talk about it
- Why might bread dough rise slowly on a cold day?
- Is a lichen one organism or two? Argue both sides.
- If protists are not a natural group, why do biologists still use the word?
- Our yeast model leaves a lot out. Name one thing it ignores.
Sources
- University of California Museum of Paleontology. Introduction to the Eukaryota. ucmp.berkeley.edu
- University of California Museum of Paleontology. Introduction to the Fungi. ucmp.berkeley.edu
- University of California Museum of Paleontology. Fungi: More on Morphology. ucmp.berkeley.edu
- University of California Museum of Paleontology. Fungi: Life History and Ecology. ucmp.berkeley.edu
- University of California Museum of Paleontology. Introduction to Lichens. ucmp.berkeley.edu
- University of California Museum of Paleontology. Introduction to the “Slime Molds”. ucmp.berkeley.edu
- University of California Museum of Paleontology. Introduction to the Bacillariophyta. ucmp.berkeley.edu
- The Editors of Encyclopaedia Britannica. Protist. Encyclopaedia Britannica. britannica.com
- Parapouli, M., Vasileiadis, A., Afendra, A.-S. and Hatziloukas, E. (2020). Saccharomyces cerevisiae and its industrial applications. AIMS Microbiology 6: 1–31. doi:10.3934/microbiol.2020001
- Salvadó, Z., Arroyo-López, F. N., Guillamón, J. M., Salazar, G., Querol, A. and Barrio, E. (2011). Temperature adaptation markedly determines evolution within the genus Saccharomyces. Applied and Environmental Microbiology 77: 2292–2302. doi:10.1128/aem.01861-10
- World Health Organization. Malaria fact sheet. who.int
- Centers for Disease Control and Prevention, DPDx. Malaria. cdc.gov
- National Oceanic and Atmospheric Administration, National Ocean Service. How much oxygen comes from the ocean? noaa.gov
- Lane, N. (2015). The unseen world: reflections on Leeuwenhoek (1677) “Concerning little animals”. Philosophical Transactions of the Royal Society B 370: 20140344. doi:10.1098/rstb.2014.0344
- Honegger, R. (2000). Simon Schwendener (1829–1919) and the dual hypothesis of lichens. The Bryologist 103: 307–313. doi:10.1639/0007-2745(2000)103[0307:SSATDH]2.0.CO;2
- Trappe, J. M. (2005). A.B. Frank and mycorrhizae: the challenge to evolutionary and ecologic theory. Mycorrhiza 15: 277–281. doi:10.1007/s00572-004-0330-5
- Frank, A. B. (1885). Über die auf Wurzelsymbiose beruhende Ernährung gewisser Bäume durch unterirdische Pilze. Berichte der Deutschen Botanischen Gesellschaft 3: 128–145. doi:10.1111/j.1438-8677.1885.tb04240.x
- Ross, R. (1897). On some peculiar pigmented cells found in two mosquitos fed on malarial blood. British Medical Journal 2: 1786–1788. doi:10.1136/bmj.2.1929.1786
- The Nobel Prize in Physiology or Medicine 1902, awarded to Ronald Ross. NobelPrize.org. nobelprize.org
- The Nobel Prize in Physiology or Medicine 1907, awarded to Alphonse Laveran. NobelPrize.org. nobelprize.org
- Alexander Fleming, Biographical. NobelPrize.org. nobelprize.org
- Fleming, A. (1929). On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzæ. British Journal of Experimental Pathology 10: 226–236. pmc.ncbi.nlm.nih.gov/articles/PMC2048009
- Chain, E., Florey, H. W. and others (1940). Penicillin as a chemotherapeutic agent. The Lancet 236: 226–228. doi:10.1016/S0140-6736(01)08728-1
- The Nobel Prize in Physiology or Medicine 1945, awarded to Alexander Fleming, Ernst Boris Chain and Howard Florey. NobelPrize.org. nobelprize.org